Scientist I or II

Posted 29 November 2023
Salary US$40 - US$58 per hour + Medical, Dental, Vision, 401k
LocationSouth San Francisco
Job type Temporary
DisciplineLife Science Recruitment
Contact NameRachael Jalbuena

Job description

Scientist I or II
Onsite in South San Francisco, CA 94080
Assignment length: 6 months-Possible extension depends on performance/business need
Hourly Rate: $40-58/hr depending on experience (employee medical insurance available at a cost)

Orion Group is seeking for an analytical minded scientist to work on-site in South San Francisco, CA for our global pharmaceutical client's Quantitaive Translational research team. In this role, you will be a scientist with hands-on experience for routinely managing mammalian cells, hepatocytes-based drug transporter assays to characterize pipeline candidate in a state-of-the art facility.

General Position Summary/Purpose:
The Quantitaive Translational ADME Science (QTAS) department is seeking a highly motivated ADME/DMPK Scientist contractor (6 months) to join the In Vitro ADME Science group (Uptake Transporter Center of Excellence). The successful candidate will work in collaboration with other team members to characterize the ADME properties of candidate drug molecules. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.

Key Accountabilities/Core Job Responsibilities:
* Routine mammalian cell culture and preservation in an efficient manner
* Handling and seeding of primary hepatocytes and recombinant cells
* Conducting HT-screening for inhibition potential on uptake transporters
* Conducting in vitro ADME/drug-drug interactions studies
* Analyzing data and maintenance of detailed, accurate and comprehensible study documentations


Education, Qualifications and Experience Requirements (degree, certifications, etc.):
* MS degree (+0 years of experience), or B.S. degree (5+ years of experience) in pharmaceutical sciences, pharmacology, biological chemistry or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development
* (Candidates with PhD/PharmD degree (0+ years of experience), MS degree (+3 years of experience), will be considered for Scientist II position.
* Excellent skills and understanding of recombinant/transiently transfected cell lines, culture, seeding, storage is must
* Working experience with hepatocytes, 2D/3D culture
* Hands-on-experience with molecular and cellular biology laboratory techniques
* Working experience with in vitro drug transporters, metabolism is a plus
* Familiarity with enzyme/transporter kinetics, data fitting
* Experience with radioisotope-based assay is a plus
* Knowledge of both biological and physicochemical properties of small molecules that influence ADME
* Experience with use of electronic lab notebook is a plus
* The individual is also expected to be organized, a team player, passionate about drug discovery, and possess effective communication skills

What are the top 3-5 skills, experience or education required for this position?
1. Cell handling (recombinant and primary cell culture, seeding)
2. In vitro Transporter assay
3. In vitro CYP450 enzyme induction assay
4. ADME/DMPK knowledge in drug discovery and development
5. Knowledge/experience in drug-drug interactions

What is a nice to have (but not required) skill, experience, education, or certification?
* Working regulatory knowledge
* IND and NDA filing
* Pipeline submission
* Experience with LC-MS/MS is a plus

Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.