Sr. Scientist (Advanced MIDD & Quantitative Systems Pharmacology)

Senior Scientist, Advanced MIDD & Quantitative Systems Pharmacology
$57 - $60/hr with medical benefits available at a cost
2 year contract
Working out of North Chicago - Hybrid schedule after training

Orion Group and our largest US client are teaming up for a new and exciting contract opportunity for Sr. Scientists in North Chicago! Our client is seeking a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations.

Don’t pass on the amazing opportunity to join a market leading pharmaceutical company!!!

Position Overview:

Pharmacometrics is concerned with the mathematical and statistical analyses and modeling of biological, pharmacological, and physiological data and processes. It quantifies the various aspects of the (desired and undesired) effects of drugs in the context of disease. The models are based on clinical data, and provide a basis for informing efficient drug development, regulatory decisions, and optimal treatment of patients. 

We are building comprehensive Model-Informed Drug Development (MIDD) capabilities in-house to create reusable platform models across our oncology portfolio. We seek a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations. You will act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.

Responsibilities Include:

• Develop QSP platform models for multiple oncology mechanisms including:
  • Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
  • Antibody-drug conjugates across lung, ovarian, and colorectal cancers
  • T-cell engagers and bispecifics/trispecifics in multiple myeloma
  • CAR-T therapies in hematologic malignancies
• Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design.
• Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization.
• Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs.
• Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group.

Qualifications Needed:

• PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development.
• Proven scientific track record and practical experience in several of the following areas.
• Statistical modeling
• Modeling with differential equations
• Scripting languages (R, Matlab, Python)
• Drug development
• Critical thinking and self-reflective
• Persistent and resilient
• Ability to connect unrelated concepts and to generate original or unique ideas
• Fluency in English required, German would be a plus

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Orion Group was founded in 1987 and is now one of the largest, independent, international recruitment companies. We have a network of 200 employees working from 24 offices, delivering a range of services – Talent Acquisition, Recruitment Outsourcing Services, Retained Search, Global Workforce Solutions, Completions & Commissioning and Materials Management – across 68 countries. As a global leader in workforce solutions, we recruit personnel across the Engineering & Technical, Office & Commercial, Scientific and Skilled Trades disciplines, for sectors including Oil & Gas, Life Science, Power & Utilities, Constructions & Infrastructure, Manufacturing and Renewables.