Scientist III

Scientist III
$65 - $69/hr with medical benefits available at a cost.
Contract length: 1 year initial contract with possibility of additional year extension.
Location: Worcester, MA - 100% Onsite
Monday through Friday 8 am to 5 pm

Orion Project Services is teaming up with a market leading pharmaceutical company on an exciting contract opportunity in Worcester, MA! Our client is in need of candidates with prior experience in biologics developability and biologics characterization using liquid chromatography- mass spectrometry (LC-MS).
 
Job Overview:
The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development Org. The Biologics CMC Developability team is responsible for- (1) the identification of biophysical- and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection, and (2) for characterization of the key CMC attributes important for biologic drug development. We have an exciting opportunity for a motivated scientist to join the Biologics CMC Developability team.

Key Responsibilities:

• Perform in-depth LC-MS based characterization of therapeutic biologic molecules and their post-translational modifications.
• Conduct liquid chromatography-based characterization of biologic drug candidates (size exclusion, ion exchange, and reverse phase).
• Execute experimental protocols, collect results, and perform data analysis carefully and independently.
• Maintain excellent documentation of work including electronic lab notebook and protocols.
• Prepare and deliver concise scientific presentations of experimental results.
• Oversee maintenance of key laboratory equipment and routine laboratory operations.
• Build strong relationships with other team members and across groups.
• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Qualifications needed to be successful in this role:

• BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 5+ (BS) or 2+ years (MS), or Ph.D. with 0+ years of biopharmaceutical industry experience.
• Hands-on experience with protein mass-spectrometry (subunit analysis, peptide mapping, disulfide mapping) and data processing is required.
• Biologics characterization using liquid chromatography- mass spectrometry (LC-MS).
• Liquid chromatography methods (size-exclusion chromatography, ion exchange, reverse-phase)
• Experience with liquid chromatography methods commonly used for characterization of biologic proteins is required.
• Experience with liquid handling robots and their programming would be highly beneficial.
• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
• Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad.
• Team player with excellent collaboration and communication skills.

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