Scientist III

Scientist III (Protein Characterization/Development)
$50 - $53/hr medical benefits available at a cost
1 year initial contract with possibility of extension
Standard 1st shift laboratory hours M-F
100% onsite in Worcester, MA

Orion Project Services is teaming up with a market leading pharmaceutical company for an exciting contract opportunity for a Scientist III out of Worcester, MA! Our client is seeking candidates proficient in protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.

Don’t pass on this amazing opportunity! Take the first step towards your next career prospect by applying today.

Job Description:
We are searching for a highly motivated Scientist to join our Analytical Development team within our Bioresearch Center in Worcester, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.

As a Scientist, you will be a part of the Analytical Characterization Group (ACG) within the Analytical Development Department. ACG focuses on providing routine, investigative, and in-depth characterization analyses of biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy and various other biophysical assays.

The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Analytical Development Department.

Key Responsibilities:

• Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA
• Perform biophysical methods (e.g., DSC) of biologics to support characterization studies.
• Design and execute experiments for method development and/or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain lab equipment.

Qualifications needed to be successful in this role:

• Bachelors or Masters in chemistry, biology, biochemistry or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.
• Knowledge of HPLC or AKTA instrumentation
• Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable.
• Knowledge of vibrational spectroscopy (e.g., IR, NIR and Raman) and multivariate analysis is desirable.
• Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).
• Excellent written communication, oral communication, organization, and multitasking skills.

Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.