Scientist III - Analytical Development

Scientist III – Analytical Development
$66 - $70/hr with medical benefits available at a cost.
Contract length- through the end of 2026
100% onsite in Worcester, MA
Standard first shift laboratory hours Monday – Friday

Orion Project Services is teaming up with a market-leading pharmaceutical company to recruit a Scientist III for its Analytical Development team in Worcester, MA. This is an exciting opportunity to support the characterization of biologics across early-stage, late-stage, and commercial programs using advanced techniques such as LC-MS, HPLC/UPLC, AKTA fractionation, spectroscopy, and biophysical assays.

The ideal candidate will have a bachelor’s degree with 5+ years of relevant industry experience or a master’s degree with 2+ years, along with hands-on experience in protein mass spectrometry and chromatography.

Job Summary:
We are searching for a highly motivated Scientist to join our Analytical Development team at our Bioresearch Center in Worcester, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.
The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Analytical Development Department.

Key Responsibilities:

• Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of AbbVie’s biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA
• Perform biophysical methods (e.g., DSC) of AbbVie’s biologics to support characterization studies.
• Design and execute experiments for method development and/or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.

Qualifications:

• Bachelors or Masters in chemistry, biology, biochemistry or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.
• Knowledge of HPLC or AKTA instrumentation
• Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable.
• Knowledge of vibrational spectroscopy (e.g., IR, NIR and Raman) and multivariate analysis is desirable.
• Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).
• Excellent written communication, oral communication, organization, and multitasking skills.
• Hardworking and motivated to drive both efficiency and quality.
  Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling of materials.

What are the top 3-5 skills, experience or education required for this position:
1.Perform separation assays such as HPLC/UPLC chromatography
2.Perform fractionation using AKTA
3.Perform LC-MS experiments on intact protein
4.Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein       characterization.
5.Excellent written communication, oral communication, organization, and multitasking skills


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