Scientist II - Cell Line Engineering Group

Scientist II – Cell Line Engineering Group
$48–$52 per hour; medical benefits available at an additional cost
Initial 1-year contract with the possibility of extension
100% onsite in Worcester, MA
Monday–Friday, 8:00 a.m.–5:00 p.m.

Orion Project Services is working with a market leading pharmaceutical company to recruit a Scientist II for its Cell Line Engineering group within Biotherapeutics Discovery. Apply your cell culture expertise to support antibody discovery and therapeutic development, with opportunities to broaden your skills in cell and molecular biology.

Working under a senior scientist’s supervision, you’ll support mammalian cell culture, knockout (KO), knock-in (KI) and overexpression (OE) cell line development, and cellular assays. You’ll also assist with laboratory operations, inventory management and sample digitization.

You’ll have opportunities to build expertise in cell and genome engineering, vector design, technology and cell-based assay development, receptor density quantification, flow cytometry, cell sorting and cloning.
Key responsibilities include:

• Culture mammalian cells, including immortalized, cancer and primary cell lines.
• Generate and maintain cell lines for antibody discovery and assay development.
• Perform cellular assays to support research activities.
• Conduct fluorescence-activated cell sorting (FACS) analysis and sorting.
• Support the development of technologies for cell line engineering.
• Consolidate historical and recent cell line assets into a digital inventory system.
• Expand and bank core cell lines to maintain adequate inventory.
• Coordinate cell line stocks across multiple sites to support the establishment of a cell bank.

Qualifications:

• Master’s degree with 3–5 years of pharmaceutical industry experience.
• Hands-on experience with mammalian cell culture is required.
• Experience with cell line engineering.
• Experience with flow cytometry.
• Experience with cell-based assays.
• CRISPR/Cas9 gene editing experience is highly desirable.

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