Scientist I ((in-vitro ADME assays))
TR/078992
Posted: 03/09/2025
- $52 - $55 per hour, Benefits: Health, Vision and Dental
- United States, California, South San Francisco
- Contract
Scientist I (in-vitro ADME assays)
$52 - $55/hr medical benefits available at a cost
6 month initial contract with possibility of extensions
Onsite laboratory position located in South San Francisco
M-F standard first shift
Orion Group has come to the bay area to team up with a market leading pharmaceutical company on an exciting contract opportunity for R&D Scientists! Our client is seeking candidates with hands-on experience in conducting in-vitro ADME assays.
Apply today and take the first step towards your next career opportunity!
General Position Summary/Purpose:
The Quantitative, Translational & ADME Sciences (QTAS) department is seeking a highly motivated fulltime contract Scientist to join the In Vitro ADME Sciences group (IVAS). The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and may work on other in vitro ADME assays. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes. Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.
Core Job Responsibilities:
Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.
$52 - $55/hr medical benefits available at a cost
6 month initial contract with possibility of extensions
Onsite laboratory position located in South San Francisco
M-F standard first shift
Orion Group has come to the bay area to team up with a market leading pharmaceutical company on an exciting contract opportunity for R&D Scientists! Our client is seeking candidates with hands-on experience in conducting in-vitro ADME assays.
Apply today and take the first step towards your next career opportunity!
General Position Summary/Purpose:
The Quantitative, Translational & ADME Sciences (QTAS) department is seeking a highly motivated fulltime contract Scientist to join the In Vitro ADME Sciences group (IVAS). The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and may work on other in vitro ADME assays. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes. Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.
Core Job Responsibilities:
- Routinely conduct (hands-on) evaluation of CYP450 induction
- Conduct qPCR assay
- Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
- Perform human and rodent hepatocytes cell culture, seeding and maintenance
- Perform cell viability assessments and use microplate reader to measure endpoints
- Contribute to the design of invitro ADME assays and data interpretation
- Analyze data and maintain detailed, accurate and comprehensible study documentations
- Use BioELN and GraphPad Prism for data analysis
- BS (1-3 years relevant experience) or MS in Biochemistry, Chemistry or Biology
- Hands-on experience in conducting in-vitro ADME assays including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes.
- Experienced with qPCR assays
- Experience with BioELN and GraphPad Prism for data analysis
- Pharmaceutical industry experienced preferred
Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.
Justin Mertel
Recruitment Consultant
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